Amidines. II. Preparation of unsymmetrical N1,N2-disubstituted amidines.

Nitrogen-bound diazeniumdiolated amidines.

In contrast to amidines bearing ionizable alpha-CH bonds, which react with nitric oxide (NO) to add diazeniumdiolate groups at their alpha-carbons, benzamidine forms an N-bound diazeniumdiolate that can be further derivatized at the other amidine nitrogen and/or the terminal oxygen to form caged NO compounds as potential NO prodrugs.

The estimation of aromatic amidines.

The inhibition of histaminase by amidines.

In normal Amount Total Error of recovery Method plasma added found (%) Spectrophotometric 079 0-5 1*28 -3-4 1*0 0.4 1*41 +2-5 -1*0 1.0 1*96 -4.0 -0-82 0-7 1-53 +1*4 -0*82 1*2 2*18 -1*7 Photoelectric 076 0 5 1F24 -4 0 -1-03 0-4 1*43 +1'2 -1-03 1.0 2*0 -3*0 -0'84 0 7 1*56 +2-8 -0*84 1*2 2*01 -2.5 Roe & Kuether (1943) -0-72 0 5 1-2 -4 0 -1.0 0.4 1*4 0.0 -1.0 1.0 1*96 -4*0 -0*88 0*7 1*6 +2-8 -0*88 ...

The determination of aromatic amidines in plasma and urine.

Certain aromatic amidines have been reported to be useful chemotherapeutic agents for the treatment of leishmaniasis, trypanosomiasis, and babesiasis (1). Pharmacological and clinical studies of these compounds have been handicapped by lack of suitable methods for the determination of aromatic amidines in plasma and urine. Recently Fuller (2) described a method which is based upon a reaction be...

Decarboxylative Palladium(II)-Catalyzed Synthesis of Aryl Amidines from Aryl Carboxylic Acids: Development and Mechanistic Investigation

A fast and convenient synthesis of aryl amidines starting from carboxylic acids and cyanamides is reported. The reaction was achieved by palladium(II)-catalysis in a one-step microwave protocol using [Pd(O2 CCF3 )2 ], 6-methyl-2,2'-bipyridyl and trifluoroacetic acid (TFA) in N-methylpyrrolidinone (NMP), providing the corresponding aryl amidines in moderate to excellent yields. The protocol is v...